Injecting Autologous Cells Could Relieve Urinary Incontinence

Tuominen & Mart SaarmaNature 448, 73-77 (5 July 2007) | doi:10.1038/nature05957Click here to vision abstract/letter online

Dr Hannes Strasser, Medical University of Innsbruck, Austria, and colleagues studied 63 women implicit burden urinary incontinence, of which 42 be given myoblast/fibroblast injection and 21 were given acknowledged endoscopic injections of collagen. All the women were given incontinence score from 0 - 6, foundation at the side of a 24-hour void chart, 24-hour wipe hypothesis test and a patient questionnaire. After 12 months, the contractibility of the rhabadosphincter (the muscle at glitch for contraction of the urethra) and the neatness of the urethra were analysed.

The researchers found that 38 of the 42 women given the autologous cell injections were altogether continent after 12 months, equate with simply two of the 21 patients given conventional collagen rehabilitation. The proposition thickness of the rhabadosphincter increased with 59% in patients given autologus cell injections, compared to a 9% advance in the collagen-injection alignment; and the contractibility of the rhabadosphincter increased by 268% in patients given the autologous cell injections, compared with 15% in the collagen-injected group. The rework in thickness of the urethra stalk not fight very much with reference to the two group.

The journalist influence their action union with other grades that suggest glory rates for shot of bulking agents such in place of collagen to immoderation urinary incontinence are impecunious. They say: "We prove that continence person in charge more in patients inject with autologous myoblasts and fibroblasts than in those injected with collagen." They conclude: "Long-term postoperative results and data from multicentre tribunal with larger numbers of patients are needed to weigh in the upper air whether injection of autologous cells into the rhabadosphincter and the urethra could become a usual treatment for urinary incontinence." In the accompanying Comment, Dr Giacomo Novara and Dr Walter Artibani, Urology Clinic, University of Padua, Italy, say: "Hannes Strasser and colleagues statement a randomised trial that can be see as the foundation of a untried aeon in urogynaecology." They conclude: "If the data are confirmed, this pose is promising to end in a huge change in the treatment of feminine stress urinary incontinence, and could become one of the peak essential innovation in urology since the enhancement of extracorporeal shockwave lithotripsy for urinary squat pummel treatment and tension-free vaginal cartridge for stress urinary incontinence."